diff --git a/lib/python/qmk/cli/generate/layouts.py b/lib/python/qmk/cli/generate/layouts.py
index ad6946d6c..4de982f82 100755
--- a/lib/python/qmk/cli/generate/layouts.py
+++ b/lib/python/qmk/cli/generate/layouts.py
@@ -85,7 +85,9 @@ def generate_layouts(cli):
 
     for alias, target in kb_info_json.get('layout_aliases', {}).items():
         layouts_h_lines.append('')
-        layouts_h_lines.append('#define %s %s' % (alias, target))
+        layouts_h_lines.append(f'#ifndef {alias}')
+        layouts_h_lines.append(f'#   define {alias} {target}')
+        layouts_h_lines.append('#endif')
 
     # Show the results
     layouts_h = '\n'.join(layouts_h_lines) + '\n'